Molecules, Vol. 17, Pages 8439-8448: Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits

This article is

• freely available
• re-usable

Article

Bruna V. Soares¹ , Selene M. Morais^1,2 , Raquel Oliveira dos Santos Fontenelle^3,?,* , Vanessa A. Queiroz² , Nadja S. Vila-Nova¹ , Christiana M. C. Pereira² , Edy S. Brito⁴ , Manoel A. S. Neto⁴ , Erika H. S. Brito⁵ , Carolina S. P. Cavalcante⁵ , D?bora S. C. M. Castelo-Branco^1,6 ?and Marcos F. G. Rocha^1,6

¹ Postgraduate Program in Veterinary Sciences, State University of Cear?, 60740-000, Fortaleza, CE, Brazil ² Department of Chemistry, State University of Cear?, 60740-000, Fortaleza, CE, Brazil ³ Centre of the Agricultural Sciences and Biological, Acara? Valley State University, 62040-370, Sobral, CE, Brazil ⁴ Embrapa Tropical Agroindustry Center, Fortaleza, 89700-000, Cear?, Brazil ⁵ Department of the Veterinary, Faculty of Veterinary Medicine, Superior Institute of Applied Theology, 62050-100, Sobral, CE, Brazil ⁶ Department of Pathology and Legal Medicine, School of Medicine, Specialized Medical Mycology Center, Federal University of Cear?, Fortaleza, 60441-750, Cear?, Brazil ^? Present address: Rua Afonso Magalh?es, 629, Apto 303: Pedrinhas. CEP: 62 042-210, Sobral, Cear?, Brazil.

* Author to whom correspondence should be addressed.

Received: 15 April 2012; in revised form: 22 June 2012 / Accepted: 30 June 2012 / Published: 11 July 2012

Abstract: The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC₅₀ value of 23 ?g/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ? 5.42 and 9.25 ? 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 ?g/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 ?g/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity.

Keywords: Coriandrum sativum; essential oil; Microsporum canis; Candida spp.; Artemia salina; linalool

Article Statistics

Click here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view. Statistics are updated once per day.

Cite This Article

MDPI and ACS Style

Soares, B.V.; Morais, S.M.; dos Santos Fontenelle, R.O.; Queiroz, V.A.; Vila-Nova, N.S.; Pereira, C.M.C.; Brito, E.S.; Neto, M.A.S.; Brito, E.H.S.; Cavalcante, C.S.P.; Castelo-Branco, D.S.C.M.; Rocha, M.F.G. Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits. Molecules 2012, 17, 8439-8448.

AMA Style

Soares B.V., Morais S.M., dos Santos Fontenelle R.O., Queiroz V.A., Vila-Nova N.S., Pereira C.M.C., Brito E.S., Neto M.A.S., Brito E.H.S., Cavalcante C.S.P., Castelo-Branco D.S.C.M., Rocha M.F.G. Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits. Molecules. 2012; 17(7):8439-8448.

Chicago/Turabian Style

Soares, Bruna V.; Morais, Selene M.; dos Santos Fontenelle, Raquel Oliveira; Queiroz, Vanessa A.; Vila-Nova, Nadja S.; Pereira, Christiana M. C.; Brito, Edy S.; Neto, Manoel A. S.; Brito, Erika H. S.; Cavalcante, Carolina S. P.; Castelo-Branco, D?bora S. C. M.; Rocha, Marcos F. G. 2012. "Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits." Molecules 17, no. 7: 8439-8448.

Source: http://www.mdpi.com/1420-3049/17/7/8439

joel ward mock draft dr oz washington redskins north country brian mcknight sbux